abstract：:Viral infections of the central nervous system (CNS) are often associated with blood-brain barrier (BBB) disruption, yet the impact of virus replication and immune cell recruitment on BBB integrity are incompletely understood. Using two-photon microscopy, we demonstrate that Venezuelan equine encephalitis virus (VEEV)...

journal_title：Journal of neuroimmunology

authors： Cain MD,Salimi H,Gong Y,Yang L,Hamilton SL,Heffernan JR,Hou J,Miller MJ,Klein RS

更新日期：2017-07-15 00:00:00

abstract：:We evaluated the impact of brain MRI findings and oligoclonal IgG bands (OCBs) on conversion to clinically definite multiple sclerosis (CDMS) in 26 Japanese patients with clinically isolated syndrome (CIS). 19.2% had OCBs positivity and 3.8% had fulfillment of Barkhof criteria at baseline. 60.0% of CIS patients with p...

journal_title：Journal of neuroimmunology

authors： Kinoshita M,Daifu M,Tanaka K,Tanaka M

更新日期：2017-06-15 00:00:00

abstract：:Large-scale genome-wide association study (GWAS) datasets provide strong support for investigations of the mechanisms underlying multiple sclerosis (MS) by using pathway analysis methods. In our recent study, we conducted a three-stage pathway analysis of GWAS and expression datasets. After identifying 15 shared MS pa...

journal_title：Journal of neuroimmunology

authors： Liu G,Zhang F,Hu Y,Jiang Y,Gong Z,Liu S,Chen X,Jiang Q,Hao J

更新日期：2017-06-15 00:00:00

abstract：:Multiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS) in which autoreactive immune cells recognizing myelin antigens lead to demyelination and axonal injury. Mechanisms relevant to the pathogenesis of MS have not been fully elucidated, particularly those underlying initiation of ...

journal_title：Journal of neuroimmunology

authors： Selmaj I,Mycko MP,Raine CS,Selmaj KW

更新日期：2017-05-15 00:00:00

abstract：:We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey ...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Nakashima I,Mugikura S,Aoki M,Fujihara K

更新日期：2017-05-15 00:00:00

abstract：:The microglia-mediated neuroinflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Advanced glycation end products (AGEs)/receptor for advanced glycation end products (RAGE) or Rho/Rho kinase (ROCK) are both involved in the development of non-specific inflammation. However, there are few...

journal_title：Journal of neuroimmunology

authors： Chen J,Sun Z,Jin M,Tu Y,Wang S,Yang X,Chen Q,Zhang X,Han Y,Pi R

更新日期：2017-04-15 00:00:00

abstract：:Interferon-β (IFN-β) is often discontinued in RRMS patients due to its most common side effect, the flu-like syndrome (FLS). The mechanisms underlying IFN β-induced FLS symptoms are still unclear. The endocannabinoid system (ECS) is a key regulator of pain and inflammation. Thus we tested the hypothesis that the ECS c...

journal_title：Journal of neuroimmunology

authors： Buttari F,Zagaglia S,Marciano L,Albanese M,Landi D,Nicoletti CG,Mercuri NB,Silvestrini M,Provinciali L,Marfia GA,Mori F,Centonze D

更新日期：2017-04-15 00:00:00

abstract：:Ketamine is a potent anti-depressive agent. Nitric oxide plays an essential role in neuronal transmission and cerebral blood flow and has been implicated in the pathophysiology of major depressive disorder as well as cardiovascular functioning. We investigated the effect of ketamine on eNOS expression in human A172 as...

journal_title：Journal of neuroimmunology

authors： Yuhas Y,Ashkenazi S,Berent E,Weizman A

更新日期：2017-04-15 00:00:00

abstract：:Magnetic resonance imaging (MRI) has led to the identification of widespread brain abnormalities in multiple sclerosis (MS) that extend far beyond the classic white matter lesion. These findings have generated the idea that MS should be understood as a disease of the whole brain, not just the white matter. While it is...

journal_title：Journal of neuroimmunology

authors： Reich DS

更新日期：2017-03-15 00:00:00

abstract：:Fatigue is a common "ghost" symptom in patients with multiple sclerosis (MS), an autoimmune disease mediated by T cells that target myelin antigens of the central nervous system. As fatigue has been associated with inflammatory states, its occurrence may negatively impact MS progression. The aim of this study was to e...

journal_title：Journal of neuroimmunology

authors： Alvarenga-Filho H,Salles M,Hygino J,Ferreira TB,Sacramento PM,Monteiro C,Vasconcelos CC,Alvarenga RM,Bento CA

更新日期：2017-02-15 00:00:00

abstract：:Caveolin-3 is a muscle-specific membrane protein that localizes to the sarcolemma and T-tubule system. Caveolin-3 is needed for muscle repair and skeletal muscle development. The objective of this study was to compare caveolin-3 expression in myasthenia gravis (MG) and control muscles. Caveolin-3 was abnormally expres...

journal_title：Journal of neuroimmunology

authors： Iwasa K,Furukawa Y,Yoshikawa H,Yamada M

更新日期：2016-12-15 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is an acute inflammatory autoimmune disease affecting the peripheral nervous system. MicroRNAs (miRNAs) are a class of small noncoding RNAs that play critical roles in the process of various diseases. The miRNAs in GBS were less studied. In this study, using microarray technology, we foun...

journal_title：Journal of neuroimmunology

authors： Lv Z,Shi Q,Huang W,Xing C,Hao Y,Feng X,Yang Y,Zhang A,Kong Q,Yuki N,Wang Y

更新日期：2016-12-15 00:00:00

abstract：OBJECTIVE:It's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of multiple sclerosis (MS). The aim of the present study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO) in MS patients compared with sex and age matched controls without MS. METHODS:T...

journal_title：Journal of neuroimmunology

authors： Zhang Y,Liu G,Duan Y,Han X,Dong H,Geng J

更新日期：2016-12-15 00:00:00

abstract：:We aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA) for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Human NF155-based ELISA clearly distinguished between anti-NF155 antibody-positive and -negativ...

journal_title：Journal of neuroimmunology

authors： Kadoya M,Kaida K,Koike H,Takazaki H,Ogata H,Moriguchi K,Shimizu J,Nagata E,Takizawa S,Chiba A,Yamasaki R,Kira JI,Sobue G,Ikewaki K

更新日期：2016-12-15 00:00:00

abstract：:Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67 is found in high proportion of patients with GAD-ab-associated neur...

journal_title：Journal of neuroimmunology

authors： Guasp M,Solà-Valls N,Martínez-Hernández E,Gil MP,González C,Brieva L,Saiz A,Dalmau J,Graus F,Ariño H

更新日期：2016-11-15 00:00:00

abstract：:For the epigenetic characterization of myasthenia gravis (MG), we determined whether long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) are expressed differentially in subjects with and without MG. Compared with healthy control subjects, the MG patients had 1561 upregulated lncRNAs, 1034 downregulated lncRNAs, 9...

journal_title：Journal of neuroimmunology

authors： Zhang F,Liu G,Bu Y,Ma X,Hao J

更新日期：2016-10-15 00:00:00

abstract：:Methylene blue (MB) is an effective neuroprotectant in many neurological disorders. AMP-activated protein kinase (AMPK)/silent mating-type information regulation 2 homolog 1 (SIRT1) plays a crucial role in maintaining inflammatory responses and shows a synergistic effect on cell homeostasis. We investigated the effect...

journal_title：Journal of neuroimmunology

authors： Wang J,Zhao C,Kong P,Bian G,Sun Z,Sun Y,Guo L,Li B

更新日期：2016-10-15 00:00:00

abstract：:Bacterial meningitis is - despite therapeutical progress during the last decades - still characterized by high mortality and severe permanent neurogical sequelae. The brain is protected from penetrating pathogens by both the blood-brain barrier and the innate immune system. Invading pathogens are recognized by so-call...

journal_title：Journal of neuroimmunology

authors： Böhland M,Kress E,Stope MB,Pufe T,Tauber SC,Brandenburg LO

更新日期：2016-10-15 00:00:00

abstract：:Sudden hearing loss may occur in rare cases of relapsing-remitting multiple sclerosis (RRMS). There have also been reports of idiopathic sudden sensorineural hearing loss (SNHL) in patients with neuromyelitis optica spectrum disorders (NMOSD), but the frequency of such cases is unclear. We conducted a retrospective an...

journal_title：Journal of neuroimmunology

authors： Tanaka M,Tanaka K

更新日期：2016-09-15 00:00:00

abstract：:Clinically isolated syndrome (CIS) is a first, usually recovering, episode of neurological disturbance(s) suggestive of multiple sclerosis (MS). CIS subjects might benefit from early disease-modifying drugs, provided that those at high risk of developing MS can be identified. Gene expression for dopaminergic receptors...

journal_title：Journal of neuroimmunology

authors： Cosentino M,Zaffaroni M,Legnaro M,Bombelli R,Schembri L,Baroncini D,Bianchi A,Clerici R,Guidotti M,Banfi P,Bono G,Marino F

更新日期：2016-09-15 00:00:00

abstract：:The pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated wit...

journal_title：Journal of neuroimmunology

authors： Dourado ME Junior,Ferreira LC,Freire-Neto FP,Jeronimo SM

更新日期：2016-09-15 00:00:00

abstract：:Although multiple sclerosis is predominantly regarded as a disease of young adulthood, up to 5% of MS patients are diagnosed prior to age eighteen. The predominant form of MS is relapsing-remitting characterized by exacerbations of symptoms followed by periods of remission. The majority of disease modifying drugs targ...

journal_title：Journal of neuroimmunology

authors： Cala CM,Moseley CE,Steele C,Dowdy SM,Cutter GR,Ness JM,DeSilva TM

更新日期：2016-08-15 00:00:00

abstract：:Contradictory results have been reported regarding the role of inflammatory mediators in the central nervous system in mediating neuropathic pain and inflammatory hyperalgesia following peripheral nerve injury or localized inflammation. The present study aims to correlate between the mRNA expression and protein secret...

journal_title：Journal of neuroimmunology

authors： Chamaa F,Chebaro M,Safieh-Garabedian B,Saadeh R,Jabbur SJ,Saadé NE

更新日期：2016-08-15 00:00:00

abstract：:Thrombin is a potent regulator of brain function in health and disease, modulating glial activation and brain inflammation. Thrombin inhibitors, several of which are in clinical use as anti-coagulants, can reduce thrombin-dependent neuroinflammation in pathological conditions. However, their effects in a healthy CNS a...

journal_title：Journal of neuroimmunology

authors： Marangoni MN,Braun D,Situ A,Moyano AL,Kalinin S,Polak P,Givogri MI,Feinstein DL

更新日期：2016-08-15 00:00:00

abstract：:Neuroadapted Sindbis virus infection of mice causes T cell-mediated fatal encephalomyelitis. In the absence of IL-10, pathogenic Th17 cells are increased and disease is accelerated. Lymphoid and myeloid cell contributions to IL-10 production were determined using VertX IL-10 transcriptional eGFP reporter mice. Effecto...

journal_title：Journal of neuroimmunology

authors： Kulcsar KA,Griffin DE

更新日期：2016-06-15 00:00:00

abstract：:Multiple sclerosis (MS) is not only an autoimmune disease in which autoreactive immune cells against myelin damage axons and nerves in the central nervous system, but also a neurodegenerative disease, in which progressive loss of structure and function of neurons occurs. The mechanisms of MS pathogenesis have not been...

journal_title：Journal of neuroimmunology

authors： Huang Q,Xiao B,Ma X,Qu M,Li Y,Nagarkatti P,Nagarkatti M,Zhou J

更新日期：2016-06-15 00:00:00

abstract：:Little is known regarding protein responses to syphilis infection in cerebrospinal fluid (CSF) of patients presenting with neurosyphilis. Protein and antibody arrays offer a new opportunity to gain insights into global protein expression profiles in these patients. Here we obtained CSF samples from 46 syphilis patient...

journal_title：Journal of neuroimmunology

authors： Lu P,Zheng DC,Fang C,Huang JM,Ke WJ,Wang LY,Zeng WY,Zheng HP,Yang B

更新日期：2016-04-15 00:00:00

abstract：BACKGROUND AND PURPOSE:The Toll-like receptor 4(TLR4)/nuclear factor kappa B NF-κB inflammatory pathway contributes to secondary inflammation in many diseases including stroke. Moreover, the neuroprotective effect of splenectomy in stroke is supported by a vast body of experimental evidence. Nevertheless, the underlyin...

journal_title：Journal of neuroimmunology

authors： Belinga VF,Wu GJ,Yan FL,Limbenga EA

更新日期：2016-04-15 00:00:00

abstract：:Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses and the underlying mechanisms in response to metformin in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Metformin reduc...

journal_title：Journal of neuroimmunology

authors： Sun Y,Tian T,Gao J,Liu X,Hou H,Cao R,Li B,Quan M,Guo L

更新日期：2016-03-15 00:00:00

abstract：:Microglia become activated immune cells during infection or disease in the central nervous system (CNS). However, the mechanisms that downregulate activated microglia to prevent immune-mediated damage are not completely understood. Vitamin D3 has been suggested to have immunomodulatory affects, and high levels of vita...

journal_title：Journal of neuroimmunology

authors： Boontanrart M,Hall SD,Spanier JA,Hayes CE,Olson JK

更新日期：2016-03-15 00:00:00

abstract：:We previously found increased microglial proliferation and pro-inflammatory cytokine release in infant mice compared to juvenile mice after hypoxia-ischemia (HI). The aim of the current study was to assess for differences in the effect of microglial suppression on HI-induced brain injury in infant and juvenile mice. H...

journal_title：Journal of neuroimmunology

authors： Cikla U,Chanana V,Kintner DB,Covert L,Dewall T,Waldman A,Rowley P,Cengiz P,Ferrazzano P

更新日期：2016-02-15 00:00:00

abstract：:Muscle weakness in MuSK myasthenia gravis (MG) is caused predominantly by IgG4 antibodies which block MuSK signalling and destabilize neuromuscular junctions. We determined whether the binding pattern of MuSK IgG4 antibodies change throughout the disease course ("epitope spreading"), and affect disease severity or tre...

journal_title：Journal of neuroimmunology

authors： Huijbers MG,Vink AF,Niks EH,Westhuis RH,van Zwet EW,de Meel RH,Rojas-García R,Díaz-Manera J,Kuks JB,Klooster R,Straasheijm K,Evoli A,Illa I,van der Maarel SM,Verschuuren JJ

更新日期：2016-02-15 00:00:00

abstract：:Migraine is believed to be a chronic neurological disorder with the exact aetiology being unknown. But, there is a debate on the role of immune dysfunction in migraine pathophysiology. Hence, authors made a debut attempt to explore the link between lymphocyte subset populations and migraine. A significant increase in ...

journal_title：Journal of neuroimmunology

authors： Arumugam M,Parthasarathy V

更新日期：2016-01-15 00:00:00

abstract：:Human Leukocyte Antigen G (HLA-G) gene polymorphism and expression rate have recently been suggested to have a potential role in susceptibility to Multiple Sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown etiology. The aim of this study was t...

journal_title：Journal of neuroimmunology

authors： Mohammadi N,Adib M,Alsahebfosoul F,Kazemi M,Etemadifar M

更新日期：2016-01-15 00:00:00

abstract：:Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects. Here, we examined the effects of berberine on dopamine receptors and the ensuing anti-inflammatory responses. Berberine was found to be an antagonist at both dopamine D1- and D2-like receptors an...

journal_title：Journal of neuroimmunology

authors： Kawano M,Takagi R,Kaneko A,Matsushita S

更新日期：2015-12-15 00:00:00

abstract：:Inflammation and immune response play a pivotal role in the pathophysiology of ischemic stroke giving their contribution to tissue damage and repair. Emerging evidence supports the involvement of epigenetic mechanisms such as methylation, histone modification and miRNAs in the pathogenesis of stroke. Interestingly, ep...

journal_title：Journal of neuroimmunology

authors： Picascia A,Grimaldi V,Iannone C,Soricelli A,Napoli C

更新日期：2015-12-15 00:00:00

abstract：:Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) influence patients' quality of life and their survival. Little is known about the pathophysiological bases of NPSLE and accordingly there are no specific therapeutic agents to be employed in this setting. Genetic research in systemic lupus erythem...

journal_title：Journal of neuroimmunology

authors： Ramirez GA,Lanzani C,Bozzolo EP,Citterio L,Zagato L,Casamassima N,Canti V,Sabbadini MG,Rovere-Querini P,Manunta P,Manfredi AA

更新日期：2015-11-15 00:00:00

abstract：:Obesity is a possible risk factor of multiple sclerosis (MS), but the association between obesity and MS disease activity has not been explored. In a cohort of 86 MS patients, 80% of overweight or obese patients (BMI≥25kg/m(2)) had MRI activity compared to 48% of the normal-weight patients (BMI<25kg/m(2)) (p=0.001) du...

journal_title：Journal of neuroimmunology

authors： Kvistad SS,Myhr KM,Holmøy T,Šaltytė Benth J,Wergeland S,Beiske AG,Bjerve KS,Hovdal H,Lilleås F,Midgard R,Pedersen T,Bakke SJ,Michelsen AE,Aukrust P,Ueland T,Sagen JV,Torkildsen Ø

更新日期：2015-11-15 00:00:00

abstract：:Gelsolin is the fourth most abundant protein in the body and its depletion in the blood has been found in multiple sclerosis (MS) patients. How gelsolin affects the MS brain has not been studied. We found that while the secreted form of gelsolin (pGSN) decreased in the blood of experimental autoimmune encephalomyeliti...

journal_title：Journal of neuroimmunology

authors： Li-ChunHsieh K,Schob S,Zeller MW,Pulli B,Ali M,Wang C,Chiou TT,Tsang YM,Lee PS,Stossel TP,Chen JW

更新日期：2015-10-15 00:00:00

abstract：:We investigated the role of intracerebroventricular (ICV) injection of rimonabant (500ng), a CB1 antagonist, on lipopolysaccharide ((LPS) 5mg/kg)-induced pulmonary inflammation in rats in an isolated perfused lung model. There were decreases in pulmonary capillary pressure (Ppc) and increases in the ((Wet-Dry)/Dry lun...

journal_title：Journal of neuroimmunology

authors： Johnson A,Neumann PH,Peng J,James J,Russo V,MacDonald H,Gertzberg N,Feleder C

更新日期：2015-09-15 00:00:00